ABSTRACT
Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride [50 mg/kg] to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Non-compartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg. min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog
Subject(s)
Animals , Injections, Intravenous , Dogs , Tetracycline/administration & dosage , Tetracycline/blood , Spectrometry, FluorescenceABSTRACT
El daño causado a la salud de los trabajadores profesionalmente expuestos a polvos de antibióticos es poco conocido. Se realizaron determinaciones ambientales de concentraciones de polvo de tetraciclina en una empresa farmacéutica dedicada a esta producción. Se estudiaron trabajadores supuestamente sanos con alta exposición a polvo de tetraciclina desde el punto de vista fisiológico y bioquímico y se analizaron las concentraciones en la sangre del producto en diversos momentos de una semana laboral. Los resultados indican que los niveles alcanzados en la sangre son similares a los de una dosis terapéutica. El sistema hepático parece ser el más dañado por la acción del fármaco. Un trabajador presentó una miopia transitoria en el desarrollo de la investigación
Subject(s)
Adult , Middle Aged , Humans , Male , Occupational Exposure , Tetracycline/bloodABSTRACT
In is study an attempt was made to measure and compare the concentrations of hostacyclin, phenoximethyl penecillin and cephalexin in normal pulp tissue and venous blood serum after 2 days of oral administration. It was found that the three antibiotics showed measurable concentrations in the three antibiotics showed measurable concentrations in pulp tissue higher than the minimum inhibitory concentrations of each. The measured pulpal concentrations were higher than half that measured in blood serum